This study was aimed to further confirm LTBP-2 selleck compound act as a novel marker in human acute heart failure. Methods and results: We demonstrated that median level of LTBP-2 in myocardial samples from heart failure patients was significantly elevated, and TGF-beta 1 significantly promoted LTBP-2 expression in neonatal rat cardiomyocytes. To investigate the potential of LTBP-2 as a biomarker to diagnose heart failure with reduced ejection fraction (HFREF), another cohort of 133 consecutive patients with dyspnea were enrolled. In receiver operating characteristic (ROC) curve analyses to detect HFREF, LTBP-2 achieved an area under curve (AUC) of

0.67 (95% confidence intervals (CI) 0.58-0.75), comparable to the diagnostic ability of NT-proBNP 0.68 (95% CI 0.59-0.77). Conclusion: The serum LTBP-2 levels might act as a promising biomarker in HFREF.”
“The human pathogenic bacterium Pseudomonas aeruginosa produces a fucose-specific lectin, LecB, implicated in tissue attachment and the formation of biofilms. To investigate if LecB inhibition GW786034 research buy disrupts these processes, high-affinity ligands were obtained

by screening two 15,536-member combinatorial libraries of multivalent fucosyl-peptide dendrimers. The most potent LecB-ligands identified were dendrimers FD2 (C-Fuc-LysProLeu)(4)(LysPheLyslle)(2) LysHislleNH(2) (IC(50) = 0.14 mu M by ELLA) and PA8 (OFuc-LysAlaAsp)(4)(LysSerGlyAla)(2) LysHislleNH(2) (IC(50) = 0.11 mu M by ELLA). Dendrimer FD2 led to complete inhibition of P. aeruginosa biofilm formation (IC(50) similar to 10 mu M) and induced complete dispersion of established biofilms in the wild-type strain and in several clinical P. aeruginosa isolates. These experiments suggest that LecB inhibition by high-affinity multivalent ligands could represent a therapeutic approach against P. aeruginosa infections by inhibition of biofilm formation and dispersion of established biofilms.”
“Introduction. In 2008, Kim’s

sham needle was developed to improve the quality of double-blinded studies. The aim of this study is to validate Kim’s sham needle by measuring facial temperature. Methods. We designed “N-of-1″ trials involving 7 smokers. One session was composed of 2 stimulations separated by a 2 h washout period. Six sessions were applied daily for all subjects. Infrared thermal www.selleckchem.com/screening/natural-product-library.html imaging was used to examine the effects of acupuncture (HT8, KI2) on facial temperature following smoking-induced decrease. Results. All subjects demonstrated decreased temperatures after sham needle treatment, but 5 of the 7 subjects showed increased temperatures after real needle treatment. 6 of the 7 subjects showed a significant difference (P < 0.05) between treatments with real and sham needles. Thus, the physiological stimulation of Kim’s sham needle is different from that of a real needle, suggesting that Kim’s sham needle is a potential inactive control intervention.

Then the supernatant from the EPO transfected FLSCs could induce the

CD34+ cell differentiated into hematopoietic cell, especially erythrocytes. This would provide an alternative for cell therapy and blood cell transfusion.”
“Objective: Bell’s palsy rarely recurs or arises bilaterally. We describe unique oral motor sequelae that manifest with bilateral facial palsy.\n\nPatients: Two rare patients with alternating Bcl-2 inhibitor bilateral Bell’s palsy experienced compromised mouth movement, affecting eating, speaking, and air exchange, and reduced quality of life.\n\nInterventions: Rehabilitation programs.\n\nMain Outcome Measures: Electromyography and electroneuronography.\n\nResults: On electromyography study, little activity of the orbicularis oris muscle was seen in any mouth or eye movement in Case 1. In Case 2, the electromyography activity of the depressor anguli oris and depressor labii inferioris muscles was stronger than that of

the orbicularis oris muscle. The 2 cases demonstrated different patterns of recovery after the same subsequent treatment.\n\nConclusion: Different patterns of reinnervation occur in bilateral Bell’s palsy. Mouth movement disturbances after bilateral Bell’s palsy are most disabling when incomplete reinnervation TPCA-1 price (as suggested by electroneuronography) of the orbicularis oris muscle occurs. Misdirection of regenerating nerve fibers produces lesser levels of oral motor impairment.”
“Objectives/Hypothesis:

The aim of this study was to describe a technique using the fascia lata (FL) component of the anterolateral thigh (ALT) flap to re-create the orbital floor and lateral nasal wall after total maxillectomy.\n\nStudy Design: Retrospective analysis of medical records.\n\nMethods: Copanlisib clinical trial A total of 22 patients underwent maxillary reconstruction using a composite ALT-FL flap following cancer resection. All patients underwent total maxillectomies via the Weber-Ferguson approach. The ALT flap was harvested with the deep fascia of the thigh with the aim of using it for lining of the orbital floor and lateral nasal cavity. The FL was sutured to the palatine bone inferiorly, nasal bone and zygomatic bone superiorly, and nasopharyngeal mucosa posteriorly to provide an orbital floor and make a neonasal cavity.\n\nResults: There was 100% free flap survival. Speech was normal in eight (36%) patients, near normal in 10 (46%), and intelligible in four (18%). Seventeen (77%) patients gained a good facial appearance, and five (23%) a fair appearance. Sixteen (73%) patients complained of mild nasal crust formation, and the rest (27%) developed moderate crust.\n\nConclusions: Microvascular reconstruction using a composite ALT-FL flap provided a reliable fascial component for orbital floor and nasal surface reconstruction of total maxillectomy defects.

\n\nCONCLUSIONS. Ocular rosacea is frequently misdiagnosed, particularly in the pediatric population. To our knowledge, this report demonstrates a case with the longest history before diagnosis (7 years) and another case in which a conjunctival biopsy was performed.”
“Radioiodine has the distinction of being the first theranostic agent

in our armamentarium. Millennia were required to PF-573228 nmr discover that the agent in orally administered seaweed and its extracts, which had been shown to cure neck swelling due to thyromegaly, was iodine, first demonstrated to be a new element in 1813. Treatment of goiter with iodine began at once, but its prophylactic value to prevent a common form of goiter took another century. After Enrico Fermi produced the first radioiodine, Sotrastaurin TGF-beta/Smad inhibitor I-128, in 1934, active experimentation in the United States and France delineated

the crucial role of iodine in thyroid metabolism and disease. I-130 and I-131 were first employed to treat thyrotoxicosis by 1941, and thyroid cancer in 1943. After World War II, I-131 became widely available at a reasonable price for diagnostic testing and therapy. The rectilinear scanner of Cassen and Curtis (Science 1949;110:94-95), and a dedicated gamma camera invented by Anger (Nature 1952;170: 200-201), finally permitted the diagnostic imaging of thyroid disease, with I-131 again the radioisotope of choice, although there were short-lived attempts to employ I-125 and I-132 for this purpose. I-123 was first produced in 1949 but did not become widely available until about 1982, 10 years after a production technique eliminated high-energy I-124 contamination. I continues to be the radioiodine of choice for the diagnosis of benign thyroid disease, whereas I-123 and I-131 are employed in the staging and detection of functioning thyroid cancer. I-124, a positron emitter, can produce excellent anatomically correlated images PRIMA-1MET order employing positron emission tomography/computed tomography

equipment and has the potential to enhance heretofore imperfect dosimetric studies in determining the appropriate administered activity to ablate/treat thyroid cancer. Issues of acceptable measuring error in thyroid cancer dosimetry and the role in I-131 therapy of tumor heterogeneity, tumor hypoxia, and kinetics must be overcome, and long-term outcome studies following I-131 given based on this new dosimetry must be completed before the nuclear medicine community will be able to predictably cure our thyroid cancer patients with this technology. Semin Nucl Med 42:164-170 (C) 2012 Elsevier Inc. All rights reserved.”
“A survey for the amphibian pathogens ranavirus and Batrachochytrium dendrobatidis (Bd) was conducted in Denmark during August and September 2008. The public was encouraged via the media to register unusual mortalities in a web-based survey.

Plasma concentrations of thalidomide were equivalent between the two strains in the SP study. There were strain differences EPZ5676 cost in some parameters, such as the post-implantation loss rate and the frequencies of malformations in forelimb and hindlimb and pulmonary intermedial lobe, but similar types of malformations or variations were induced at the same dose levels on the same dosing period in both strains. Therefore, it is concluded that there were no essential differences in sensitivity of the fetuses to thalidomide between Kbl:JW and NZW rabbits and both of the strains are useful

to evaluate the teratogenic effects of thalidomide.”
“The prevent mother-to-child transmission (PMTCT) cascade describes the programmatic steps for pregnant and breastfeeding

women that influence HIV transmission rates. To this end, HIV-infected pregnant women and mothers need access to health services and adhere to antiretroviral (ARV) prophylaxis or lifetime treatment. Within the cascade, the concept of retention-in-care is commonly used as a proxy for adherence to ARV interventions and, even, viral suppression. Yet surprisingly, there is no standard definition of retention-in-care either for the purposes of HIV surveillance or implementation research. Implicit to the concept of retention-in-care is the sense of continuity and receipt of care at relevant time points. In the context of PMTCT, the main challenge for surveillance and implementation research is to estimate effective coverage of ARV interventions over a prolonged period of time. These data CH5424802 research buy are used to inform program management and also to estimate postnatal MTCT rates. Attendance Semaxanib of HIV-infected mothers at clinic at 12-month postpartum is often equated with full retention in PMTCT programs over this period. Yet, measurement approaches that

fail to register missed visits, or inconsistent attendance or other missing data in the interval period, fail to capture patterns of attendance and care received by mothers and children and risk introducing systematic errors and bias. More importantly, providing only an aggregated rate of attendance as a proxy for retention-in-care fails to identify specific gaps in health services where interventions to improve retention along the PMTCT cascade are most needed. In this article, we discuss how data on retention-in-care can be understood and analyzed, and what are the implications and opportunities for programs and implementation research.”
“Abnormal expression of anaplastic lymphoma kinase (ALK) gene is an important pathogenic factor for anaplastic large cell lymphoma (ALCL). To study the function of ALK, an inducible short hairpin RNA (shRNA) system was stably introduced into cultured human ALCL cells.

96 and a root mean square error (RMSE) of approximately 17 mg l(-1). The validation analysis showed that the algorithm could estimate the TSS concentration within an RMSE of about 23 mg l(-1) and an R value of 0.95. The calibrated algorithm was used to generate water quality maps for all images. The maps were geometrically RO4929097 ic50 corrected and colour coded for visual interpretation.”
“The primary causative agent of tick-borne relapsing fever in North America is Borrelia hermsii. It has been hypothesized that B. hermsii

evades complement-mediated destruction by binding factor H (FH), a host-derived negative regulator of complement. In vitro, B. hermsii produces a single FH binding protein designated FhbA (FH binding protein A). The properties and ligand binding activity of FhbA suggest that it plays multiple roles in

pathogenesis. It binds plasminogen and has been identified as a significant target of a B1b B cell-mediated IgM response in mice. FhbA has also been explored as a potential diagnostic antigen for B. hermsii infection in humans. The ability to test the hypothesis that FhbA is a critical virulence factor in vivo has been hampered by the lack of well-developed systems for the genetic manipulation of the relapsing fever spirochetes. In this report, we have successfully generated a B. hermsii fhbA deletion mutant (the B. hermsii YOR Delta fhbA strain) through allelic exchange mutagenesis. Deletion of fhbA abolished FH binding by the YOR Delta fhbA strain and eliminated cleavage of C3b on the cell surface. However, the YOR Delta fhbA strain remained infectious in mice and retained resistance to killing in vitro by human complement.

MRT67307 purchase Collectively, these results indicate that B. hermsii employs an FhbA/FH-independent mechanism of complement evasion that allows for resistance to killing by human complement and persistence in mice.”
“Background: This study aimed to identify and select informative Simple Sequence Repeat (SSR) markers that may be linked to resistance to important groundnut diseases such as Early Leaf Spot, Groundnut Rosette Disease, rust and aflatoxin contamination. To this end, 799 markers were screened across 16 farmer preferred and other cultivated African groundnut varieties that are routinely used in groundnut improvement, some with known resistance traits. Results: The CBLC137 HCl SSR markers amplified 817 loci and were graded on a scale of 1 to 4 according to successful amplification and ease of scoring of amplified alleles. Of these, 376 markers exhibited Polymorphic Information Content (PIC) values ranging from 0.06 to 0.86, with 1476 alleles detected at an average of 3.7 alleles per locus. The remaining 423 markers were either monomorphic or did not work well. The best performing polymorphic markers were subsequently used to construct a dissimilarity matrix that indicated the relatedness of the varieties in order to aid selection of appropriately diverse parents for groundnut improvement.

For the first time, we report the use of interleukin-2 to stimulate a graft-versus-leukemia effect and induce complete remission in a patient with BRCA2 Fanconi anemia and refractory acute myelogenous leukemia, suggesting the potential of immunotherapy in this setting. Interleukin-2 was associated with significant infusion-related toxicity.”
“N-Heteroaromatics HetNH, such as pyrrole (1), indole (2) and carbazole (3), have been selectively N-carbonylated by a direct reaction with diphenyl carbonate Selleck JQ1 (DPC), used as an environmental friendly carbonyl active species in place of toxic and hazardous phosgene. The carbonylation reaction can be effectively catalyzed

by 1,8-diazabicyclo[5.4.0]undec-7-ene

(DBU), which can act as a base catalyst by selleck compound activating the HetNH substrate, and as a nucleophile catalyst by activating the organic carbonate. The influence of reaction parameters (temperature, reaction time, DBU load, DPC/HetNH molar ratio) on the productivity of the process has been also investigated. The synthetic methodology does not require severe temperature conditions, is solventless, simple (only one step), efficient and selective, and offers a new solution to the synthesis of synthetically versatile HetNCO(2)Ph derivatives through a route alternative to the current traditional phosgenation methods.”
“OBJECTIVE: To investigate the hemodynamie and outcome effects of implementing prophylactic positive end-expiratory

pressure (PEEP) versus zero end-expiratory Ulixertinib pressure (ZEEP) in patients during the postintubation period in the emergency setting.\n\nMETHODS: The present study was a prospective, single-centre, interventional, single-blinded randomized trial performed in a 16-bed medical intensive care unit. The study cohort consisted of consecutive patients who urgently required intubation. During the postintubation period, patients received either 5 cmH(2)O PEEP or ZEEP. The primary aim was to assess the variation in mean arterial pressure (MAP) from baseline up to 90 min postintubation. The secondary aim was to determine the mean duration of intubation, level of MAP support after intubation and 28-day mortality.\n\nRESULTS: Seventy-five consecutive patients with similar mean (+/- SD) baseline characteristics and preintubation MAP (76 +/- 18 mmHg in the ZEEP group and 78.5 +/- 23 mmHg in the PEEP group, P=Not significant [NS]) were studied. The final analysis was performed in 33 patients in the ZEEP group and 30 patients in the PEEP group. Regarding outcome measures following intubation, delta MAP (ie, the difference between the lowest MAP values from baseline) was not differentially affected in either group (P=NS); the mean durations of intubation were similar (ZEEP 9.2 +/- 8.5 days versus PEEP 9.2 +/- 8.

cm(-2).nm(-1) (confirmed with an appropriate irradiance meter calibrated over the appropriate wavelength range); (3) illumination of maximal body surface; and (4) demonstration of a decrease in total bilirubin concentrations during the first 4 to 6 hours of exposure.\n\nRECOMMENDATIONS (SEE APPENDIX FOR GRADING DEFINITION): The intensity and spectral output of phototherapy devices is useful in predicting potential effectiveness in treating hyperbilirubinemia (group B recommendation). Clinical Metabolism inhibitor effectiveness should be evaluated before and monitored during use (group B recommendation). Blocking the light source or reducing exposed body

surface should be avoided (group B recommendation). Standardization of irradiance meters, improvements in device design, and lower-upper limits of light intensity for phototherapy units merit further study. Comparing the in vivo performance of devices is not practical, in general, and alternative procedures need to be explored. Pediatrics 2011;128:e1046-e1052″
“Understanding variations in lipoprotein cholesterol levels throughout the menstrual cycle is important because there may be clinical implications GS-7977 regarding

the appropriate timing of measurement and implications on the design and interpretation of studies in women of reproductive age. Our objective was to review the evidence comparing lipoprotein cholesterol levels throughout the menstrual cycle among premenopausal women. Overall, lipoprotein SRT1720 cholesterol levels were observed to vary in response to changing estrogen levels. Taken together, the evidence

suggests that total cholesterol and LDL-C tend to be highest during the follicular phase and to decline during the luteal phase, with HDL-C highest around ovulation. Based on these findings, the menstrual cycle phase should be taken into account when evaluating lipoprotein cholesterol levels among reproductive-aged women. Measuring cholesterol levels during menses is recommended for consistent comparisons as this phase can be more reliably identified than other phases, although women within National Cholesterol Education Program acceptable ranges, but near the boundaries when tested during menses, should undergo additional tests.”
“A new lab-scale microstructured reactor was used for investigations on enhancing the H-2/CO ratio in synthesis gas from biomass feedstocks via the water gas shift reaction. A model mixture of carbon monoxide, carbon dioxide, water, and hydrogen was used to reproduce the typical synthesis gas composition from dry biomass gasification. Catalyst layers were prepared and characterized; a combined incipient wetness impregnation and sol-gel technology was applied. The catalytic activities of Pt/CeO2 and Pt/CeO2/Al2O3 films were determined at temperatures of 400-600 degrees C and pressures of up to 45 bars.

Ovaries were collected from mature, cyclic (d 3 to 6) Twinner (n = 11), and

Control (n = 12) cows at slaughter and pieces of cortical tissue were fixed and embedded in paraffin. Expression of mRNA was evaluated by in situ hybridization using S-35-UTP-labeled antisense and sense probes for CYP19A1, FSHR, IGF1, and IGF2R mRNA. Silver grain density was quantified within the granulosa and theca cells of individual follicles (2 to 7 follicles/cow) by Bioquant image analysis. Follicles of Twinners tended to be smaller in diameter than Controls (1.9 +/- 0.1 vs. 2.3 +/- 0.1 mm; P = 0.08), but thickness of granulosa layer did not differ (P > 0.1) by genotype. Relative abundance of CYP19A1 (P < 0.01) and FSHR (P < 0.05) mRNA was greater in granulosa cells of Twinners vs. Controls, respectively, whereas IGF2R mRNA expression was less in both granulosa (P < 0.01) and theca (P Dinaciclib solubility dmso < Anlotinib cell line 0.05) cells in follicles of Twinners vs. Controls, respectively. Abundance of CYP19A1 mRNA in granulosa cells was correlated negatively with IGF2R mRNA expression in both granulosa (r = -0.33; P < 0.01) and

theca (r = -0.21; P = 0.05) cells. Expression of IGF1 mRNA was primarily in granulosa cells, including cumulus cells, and its expression did not differ between Twinners vs. Controls (P > 0.10). Detected increases in CYP19A1 and FSHR, but not IGF1, mRNA expression along with decreases in IGF2R mRNA expression in individual follicles of Twinners support the hypothesis that increased follicular

development and steroidogenesis in Twinner females result from increased extra-ovarian IGF-1 production. Furthermore, a reduction in follicular IGF2R mRNA expression accompanied by a reduction in receptor numbers would increase availability of free IGF-2 and its stimulation of follicular development in Twinners.”
“Echocardiography in birds is a useful and competent technique for morphological and functional www.selleckchem.com/products/AZD1480.html cardiac assessment. The aim of this study was to establish normal reference echocardiographic values for ostrich. Echocardiographic parameters from 25 apparently healthy male and almost 4 month old ostrich were chosen for this experiment. Echocardiography was prepared from the second and third intercostals space and over the sternum. The mean and standard deviation was calculated for each parameter. The values obtained are: The left ventricular internal diameter at end systole and end diastole was 1.50 +/- 0.2 and 2.70 +/- 0.16 cm; left ventricular free wall at end systole and end diastole was 0.89 +/- 0.04 and 0.62 +/- 0.03 cm; inter ventricular septum at end systole and end diastole was 0.99 +/- 0.81 and 0.65 +/- 0.11 cm, respectively. The stroke volume was 20.98 +/- 2.

This highlights the potential of combined carbon and nitrogen isotopes analysis to trace sources and degradation of glyphosate.”
“Most antibacterial peptides exhibit low therapeutic indices in vivo.

Peptide A3-APO was shown to exhibit high potency against Escherichia coli bacteremia when added intraperitoneally. To extend the studies to systemic infections against multidrug-resistant organisms, we studied the efficacy of A3-APO in mouse models of carbapenem-resistant Acinetobacter baumannii infection. When administered either intravenously at 2.5 mg/kg or intramuscularly (im) at 5 mg/kg twice or three times to mice infected with a carbapenem-resistant A. baumannii strain, peptide A3-APO reduced the bacterial counts by at least two log(10) units and increased the survival rate compared with untreated animals or mice treated with 40 mg/kg imipenem. Unlike after intraperitoneal selleck chemicals llc or intravenous administration, A3-APO did not show toxic effects at 60 mg/kg dose im. (C) 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 96: 126-129, 2011.”
“We reported previously that concentric

or eccentric exercise can lead to errors in human limb see more position sense. Our data led us to conclude that the errors, post-exercise, were not due to an altered responsiveness of the proprioceptive afferents, and we proposed that they resulted from central changes in the processing of the afferent input. However, it remained uncertain what was responsible learn more for triggering those changes, the volume of afferent traffic during the exercise or the developing fatigue. The afferent traffic hypothesis was tested by subjects carrying out a series of 250 lightly loaded concentric contractions of elbow flexors that produced little fatigue (6 %). This did not lead to significant position errors. In a second experiment, a series of fatiguing isometric contractions, which kept movements of the muscle to a minimum, led to

a 24 % fall in force and significant position errors (3A degrees, direction of extension). In the third experiment, at 24 h after eccentric exercise, when the short-term effects of fatigue and accumulated metabolites were gone, but force was still 28 % below control values, this was accompanied by significant position errors in the direction of extension, 3.2A degrees in the relaxed arm and 3.3A degrees in the self-supported arm. It is concluded that it is the fall in force accompanying exercise which is responsible for disturbing limb position sense. It is suggested that the exercise effects are generated in the brain, perhaps as a result of an alteration of the body map, triggered by the fall in force.”
“Adolescents drink largely in social situations, likely in an attempt to facilitate social interactions. This study sought to examine alterations in the incentive salience of a social stimulus following repeated stress exposure and acute ethanol administration in adolescent and adult male Sprague-Dawley rats.

“
“Vascular complications of wrist arthroscopy are rare. We report the case of a 42-year-old male patient with a history of hemophilia who had a ganglion located where the radial pulse is taken that had been causing him pain for five months. After infusion of Exacyl (antifibrinolytic agent), the ganglion was drained arthroscopically. Fifteen days later, the patient presented with a pseudoaneurysm of the radial artery requiring urgent reoperation. (C) 2014 Elsevier Masson SAS. All rights reserved.”
“Zingiber officinule (ZO), commonly known

as ginger, has been traditionally used in the treatment of diabetes mellitus. Several studies have reported the hypoglycaemic properties of ginger in animal models. The present study evaluated Eltanexor research buy the antihyperglycaemic effect of its aqueous extract administered orally (daily) in three different doses (100, 300, 500 mg/kg body weight) for a period of 30 d to streptozotocin (STZ)-induced diabetic rats. A dose-dependent antihyperglycaemic effect revealed a decrease of plasma glucose levels by 38 and 68% on the 15th and 30th day, respectively, after the rats were given 500 mg/kg. The 500 mg/kg ZO significantly (P<0.05) decreased kidney weight (%

body weight) in ZO-treated diabetic rats v. control rats, although the decrease in liver weight (% body weight) was not statistically significant. Kidney glycogen content increased significantly (P<005) while liver and skeletal muscle glycogen content decreased significantly (P<005) in diabetic controls v. normal controls. ZO (500 mg/kg) also significantly decreased kidney glycogen (P<005) AZD6244 and increased liver and skeletal muscle glycogen in STZ-diabetic rats when compared to diabetic controls. Activities of glucokinase, phosphofructokinase and pyruvate kinase in Selleck Screening Library diabetic controls were decreased by 94, 53 and 61 %, respectively, when compared to normal controls; and ZO significantly increased (P<0.05) those enzymes’ activities

in STZ-diabetic rats. Therefore, the present study showed that ginger is a potential phytomedicine for the treatment of diabetes through its effects on the activities of glycolytic enzymes.”
“The biological threat imposed by orthopoxviruses warrants the development of safe and effective vaccines. We developed a candidate orthopoxvirus DNA-based vaccine, termed 4pox, which targets four viral structural components, A33, B5, A27, and L1. While this vaccine protects mice and nonhuman primates from lethal infections, we are interested in further enhancing its potency. One approach to enhance potency is to include additional orthopoxvirus immunogens. Here, we investigated whether vaccination with the vaccinia virus (VACV) interferon (IFN)-binding molecule (IBM) could protect BALB/c mice against lethal VACV challenge. We found that vaccination with this molecule failed to significantly protect mice from VACV when delivered alone.